SS-31
Mitochondria-targeting tetrapeptide (elamipretide) studied for cardiolipin protection and oxidative-stress research.
Overview
SS-31 (also known as elamipretide) is a synthetic tetrapeptide designed to concentrate in the inner mitochondrial membrane, where it binds the phospholipid cardiolipin.
It is one of the most-studied mitochondria-targeting research peptides, of interest in oxidative-stress, mitochondrial-function, and cellular-energy research models.
Mechanism of interest
- Cardiolipin binding — studied for stabilizing the mitochondrial-membrane scaffolding that the energy machinery sits on.
- Oxidative-stress reduction — investigated for limiting reactive-oxygen-species leakage in research models.
- Mitochondrial function — examined for effects on ATP production and bioenergetics.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C, protected from light.
- Reconstitute with bacteriostatic water; refrigerate at 2–8°C after reconstitution.
- Avoid repeated freeze/thaw cycles.
Selected references
- 1.Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent to reverse mitochondrial dysfunction (SS-31 / elamipretide). Br J Pharmacol. 2014.
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