Retatrutide
Triple agonist (GLP-1 / GIP / glucagon) research peptide. Available in 10, 15, and 30 mg vials.
Overview
Retatrutide (research code LY3437943) is a single-molecule triple agonist that simultaneously targets the glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors.
It is one of the most studied next-generation incretin research compounds, of interest in metabolic and body-composition research models for its combined receptor activity.
Current batches are independently verified by an ISO 17025-accredited laboratory — chromatographic purity by HPLC-UV/VIS, plus sterility (USP <71>) and bacterial endotoxin (LAL) testing. See the Certificates of Analysis below.
Mechanism of interest
- GLP-1 receptor agonism — the most established incretin pathway in metabolic research.
- GIP receptor agonism — studied alongside GLP-1 for additive incretin effects.
- Glucagon receptor agonism — investigated for its role in energy expenditure in research models.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C; stable for extended periods when kept frozen and dry.
- Reconstitute with bacteriostatic water. Once reconstituted, refrigerate at 2–8°C and use within the researcher's validated window.
- Avoid repeated freeze/thaw cycles. Protect from light.
Certificates of Analysis
Batch-specific purity, independently verified by HPLC.
| Lot | Purity | Method | Date | COA |
|---|---|---|---|---|
BG4MA Vanguard Laboratory (ISO 17025) | 99.80% | HPLC-UV/VIS | 2026-02 | Download ↓ |
RET-260210-B1 Testides | 99.68% | HPLC-UV | 2026-02 | Download ↓ |
Selected references
- 1.Jastreboff AM, et al. Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. N Engl J Med. 2023.
- 2.Coskun T, et al. LY3437943, a novel triple GIP/GLP-1/glucagon receptor agonist. Cell Metab. 2022.
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Create account →All products are sold for laboratory and research use only. Not for human consumption, diagnosis, treatment, or cure of any condition. Not evaluated by the FDA.