Semax
ACTH(4–7) analog heptapeptide studied for BDNF and dopamine signalling in nootropic research.
Overview
Semax is a synthetic heptapeptide derived from a fragment of ACTH (adrenocorticotropic hormone) with an added Pro-Gly-Pro tail for stability.
Developed in the Russian research lineage, it is studied in cognition, memory, and neuroprotection research models — frequently paired with Selank.
Mechanism of interest
- BDNF signalling — research associates it with increased brain-derived neurotrophic factor in study models.
- Dopamine pathways — studied for effects on dopaminergic signalling linked to attention.
- Neuroprotection — investigated in models of oxidative and ischemic stress.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C, protected from light.
- Reconstitute with bacteriostatic water; refrigerate at 2–8°C after reconstitution.
- Avoid repeated freeze/thaw cycles.
Selected references
- 1.Dolotov OV, et al. Semax, an analog of ACTH(4–10), increases BDNF expression in the rat hippocampus. Neurosci Lett. 2006.
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