PT-141
Melanocortin-receptor agonist (bremelanotide) studied in sexual-function and libido research models. Single 10 mg vial.
Overview
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH) and an active metabolite of melanotan II, developed as a melanocortin-receptor agonist.
Unlike vasodilator research compounds that act on the peripheral vasculature, PT-141 is studied for its action on central melanocortin pathways, making it a distinct tool compound in sexual-behavior and libido research models.
Current batch is independently verified — chromatographic purity by HPLC-UV with identity confirmed by mass spectrometry (LC-MS). See the Certificate of Analysis below.
Mechanism of interest
- Melanocortin-receptor agonism — activates central melanocortin receptors (principally MC4R, with MC3R activity) in research models.
- Central pathway — studied for modulating sexual-arousal signaling upstream of the vascular effects targeted by PDE5-inhibitor research.
- α-MSH analog — a cyclic heptapeptide derived from the melanotan II scaffold, investigated for melanocortin-system signaling.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C, dry and protected from light.
- Reconstitute with bacteriostatic water; refrigerate at 2–8°C after reconstitution and use within the researcher's validated window.
- Avoid repeated freeze/thaw cycles.
Certificates of Analysis
Batch-specific purity, independently verified by HPLC.
| Lot | Purity | Method | Date | COA |
|---|---|---|---|---|
P41-260723 | 99.43% | HPLC-UV / LC-MS | 2026-07 | Download ↓ |
Selected references
- 1.Molinoff PB, Shadiack AM, Earle D, Diamond LE, Quon CY. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003.
- 2.Kingsberg SA, Clayton AH, Portman D, et al. Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder: Two Randomized Phase 3 Trials. Obstet Gynecol. 2019.
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