MOTS-c
Mitochondrial-derived peptide studied in metabolic regulation, insulin-sensitivity, and exercise-metabolism research.
Overview
MOTS-c is a mitochondrial-derived peptide (a short peptide encoded within mitochondrial DNA) that has become a focus of metabolic research.
It is investigated in models of metabolic homeostasis, insulin sensitivity, and exercise physiology for its proposed role in cellular energy regulation.
Mechanism of interest
- Metabolic regulation — studied for maintaining metabolic homeostasis in research models.
- AMPK pathway — investigated for activating the AMPK energy-sensing pathway.
- Mitochondrial signaling — examined as a mitochondrial-to-nucleus signaling peptide in the literature.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C, protected from light.
- Reconstitute with bacteriostatic water; refrigerate at 2–8°C after reconstitution.
- Avoid repeated freeze/thaw cycles.
Certificates of Analysis
Batch-specific purity, independently verified by HPLC.
| Lot | Purity | Method | Date | COA |
|---|---|---|---|---|
JE020126S1 Freedom Diagnostics | 99.90% | HPLC-UV / MS | 2026-02 | Download ↓ |
TB122525S1 Freedom Diagnostics | 99.42% | HPLC-UV / MS | 2025-12 | Download ↓ |
Selected references
- 1.Lee C, et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015.
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