DSIP
Delta Sleep-Inducing Peptide — a nonapeptide studied in slow-wave sleep and stress-response research.
Overview
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first identified for its association with delta (slow-wave) brain activity during deep sleep.
It is studied in sleep-architecture, circadian, and stress-response research models — of interest for its proposed role as a short-acting sleep-stage signal rather than a sedative.
Mechanism of interest
- Slow-wave signalling — studied for shifting brain activity toward delta-wave, deep-repair sleep in research models.
- Stress-axis modulation — investigated for effects on the HPA axis and stress hormones.
- Short-acting signal — characterized in the literature as transient rather than long-lasting.
Research areas
Handling & storage
- Lyophilized powder. Store sealed vials at -20°C, protected from light.
- Reconstitute with bacteriostatic water; refrigerate at 2–8°C after reconstitution.
- Avoid repeated freeze/thaw cycles.
Selected references
- 1.Kovalzon VM, Strekalova TV. Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006.
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